RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; Masson's trichrome staining etc.
Target
SMAD4
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4
Year
2014
Function
"Overexpressing miR-34a levels increased the profibrogenic activity of TGF-beta1 in cardiac fibroblast, whereas inhibition miR-34a levels weakened the activity."